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Updated: Jan 3, 2026

Counting Proteins in Single Cells with Addressable Droplet Microarrays

Counting Proteins in Single Cells with Addressable Droplet Microarrays

Published on: July 6, 2018

Mini-pillar microarray for individually electrochemical sensing in microdroplets.

Yongchao Song¹, Tailin Xu¹, Jidong Xiu¹

¹Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, 100083, PR China.

Biosensors & Bioelectronics

|November 17, 2019

Summary

This summary is machine-generated.

This study introduces a novel mini-pillar microarray for high-throughput, high-sensitivity electrochemical sensing in microdroplets. This platform enables precise detection of multiple biomarkers, advancing drug discovery and biochemical analysis.

Keywords:

Individually sensing Microdroplets array Mini-pillar electrochemical platform

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Last Updated: Jan 3, 2026

Counting Proteins in Single Cells with Addressable Droplet Microarrays

Counting Proteins in Single Cells with Addressable Droplet Microarrays

Published on: July 6, 2018

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

A Microfluidic Chip for ICPMS Sample Introduction

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Area of Science:

Biomedical Engineering
Analytical Chemistry
Microfluidics

Background:

High throughput and sensitivity are critical for biomarker recognition, drug discovery, and biochemical sensing.
Existing methods face challenges in achieving both high throughput and individual sample analysis.

Purpose of the Study:

To develop a novel mini-pillar microarray integrated with circuit components for high-throughput individual electrochemical sensing in microdroplets.
To demonstrate the platform's capability for sensitive and quantitative analysis of multiple analytes.

Main Methods:

Integration of mini-pillar microarray with electrochemical circuit components.
Utilizing mini-pillars for stable microdroplet containment (hundreds nanoliter to few microliter).
Employing a three-electrode system on each pillar for individual electrochemical sensing and sequential readout.

Main Results:

Successful high-throughput individual electrochemical sensing in microdroplets.
Demonstration of qualitative and quantitative electrochemical assessments of glucose concentrations.
The mini-pillar adhesion effectively holds microdroplets during rotation and deformation.

Conclusions:

The mini-pillar-based electrochemical platform offers a promising solution for high-throughput and high-sensitivity biomolecular recognition.
This technology provides an opportunity for developing miniaturized sensing platforms for biological and pathological applications.