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Related Concept Videos

Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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Patch Clamp01:18

Patch Clamp

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
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Related Experiment Video

Updated: Jan 3, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
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Procalcitonin: Where Are We Now?

Bachar Hamade1, David T Huang2

  • 1Department of Emergency Medicine, American University of Beirut Medical Center, 2nd Floor, Cairo Street, Beirut, Lebanon; Department of Critical Care Medicine, University of Pittsburgh Medical Center, 3550 Terrace Street, Room 651, Scaife Hall, Pittsburgh, PA 15261, USA.

Critical Care Clinics
|November 18, 2019
PubMed
Summary

Procalcitonin is a biomarker useful for identifying bacterial infections. This review examines its application, drawing parallels with troponin, to guide clinical use and testing strategies.

Keywords:
AntibioticsMortalityProcalcitoninRespiratory tract infectionSepsis

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Area of Science:

  • Biomarker research
  • Clinical diagnostics
  • Infectious disease management

Background:

  • Procalcitonin (PCT) is a well-established biomarker for bacterial infections.
  • Understanding biomarker utility requires a robust conceptual framework.
  • The history of troponin provides valuable lessons for biomarker development and application.

Purpose of the Study:

  • To present a conceptual framework for evaluating biomarkers.
  • To apply this framework to procalcitonin, assessing its role in bacterial infections.
  • To provide clinical recommendations for procalcitonin use and testing.

Main Methods:

  • Review of observational studies and randomized controlled trials.
  • Comparative analysis using the troponin biomarker framework.
  • Synthesis of evidence from intensive care unit (ICU) and non-ICU settings.

Main Results:

  • Procalcitonin exhibits significant potential as a biomarker for bacterial infections.
  • The troponin framework effectively elucidates procalcitonin's diagnostic and prognostic value.
  • Evidence supports procalcitonin's utility in guiding antibiotic therapy and patient management.

Conclusions:

  • A structured approach enhances the understanding and application of biomarkers like procalcitonin.
  • Clinical guidelines should incorporate evidence-based recommendations for procalcitonin testing.
  • Further research on optimizing biomarker testing strategies is warranted.