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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Jan 3, 2026

Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
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B7-H4, a promising target for immunotherapy.

Jia-Yu Wang1, Wei-Peng Wang1

  • 1Center for Drug Metabolism and Pharmacokinetics, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.

Cellular Immunology
|November 18, 2019
PubMed
Summary

B7-H4, a coinhibitory molecule, is crucial in immune regulation and disease. Its abnormal expression impacts tumors, inflammation, and autoimmune disorders, making it a potential therapeutic target.

Keywords:
B7-H4Immune escapeImmunotherapyRegulatory mechanismTumorigenesis and tumor development

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Area of Science:

  • Immunology
  • Oncology
  • Endocrinology

Background:

  • B7-H4 is a coinhibitory molecule in the B7 family.
  • It negatively regulates T cell responses and promotes immune escape.
  • Abnormal B7-H4 expression is linked to tumors, inflammation, and autoimmune diseases.

Purpose of the Study:

  • To summarize the expression, functions, and regulatory mechanisms of B7-H4.
  • To review signaling pathways involving B7-H4.
  • To explore B7-H4-based immunotherapy.

Main Methods:

  • Literature review of B7-H4 expression profiles.
  • Analysis of physiological and pathological functions.
  • Investigation of regulatory mechanisms and signaling pathways.

Main Results:

  • B7-H4 inhibits T cell proliferation, cytokine secretion, and cell cycle.
  • It plays a key role in tumorigenesis, invasion, metastasis, and anti-apoptosis.
  • B7-H4 also protects against type 1 diabetes and aids islet cell transplantation.

Conclusions:

  • B7-H4 is a significant factor in immune regulation and various diseases.
  • Its multifaceted roles establish it as a potential therapeutic target.
  • Further research into B7-H4-based therapies is warranted for cancer and autoimmune diseases.