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Related Experiment Video

Updated: Jan 3, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

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Link between personality and response to THC exposure.

Tetiana Kardash1, Dmitry Rodin2, Michael Kirby1

  • 1Department of Molecular Biology, Ariel University, Ariel, Israel.

Behavioural Brain Research
|November 18, 2019
PubMed
Summary

Cannabis (THC) effects vary. Stress-resilient mice showed no aversion, while stress-sensitive mice avoided THC at high doses. Individual stress vulnerability influences cannabis response.

Keywords:
AddictionAversionBehaviorCannabisPersonalityTHC

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Last Updated: Jan 3, 2026

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Cannabis (THC) elicits diverse user effects, from euphoria to anxiety and depression.
  • Contradictory responses to cannabis remain poorly understood.
  • Individual differences in stress resilience may explain varied cannabis effects.

Purpose of the Study:

  • To investigate how stress resilience and dominance influence responses to delta-9-tetrahydrocannabinol (THC).
  • To elucidate the mechanisms behind contradictory cannabis user experiences.

Main Methods:

  • Utilized selectively-bred stress-resilient (Dom) and stress-sensitive (Sub) mice.
  • Administered two doses of THC (1.5 mg/kg and 15 mg/kg) in short-term, repeated treatments.
  • Assessed behavioral responses using Conditioned Place Preference and Forced Swim tests after a 6-week washout period.
  • Measured serum corticosterone levels.

Main Results:

  • Sub mice exhibited place aversion to high-dose THC, while Dom mice showed no preference or aversion.
  • Low-dose THC alleviated depressive-like behavior in Sub mice; high-dose THC exacerbated it in Dom mice.
  • High-dose THC elevated corticosterone levels in both mouse populations.

Conclusions:

  • Dominance behavior and stress vulnerability significantly regulate individual responses to THC.
  • These factors are crucial for understanding cannabis effects and guiding clinical prescriptions of THC-containing medications.