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Updated: Jan 3, 2026

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
[Malignant arterial hypertension (HTAM) with severe systolic dysfunction of the reversible left ventricle]
M S Cortés Fernández1, J P Monteys Montblanch2, P Castellanos Lleuger1
1Área Atención Integrada de Riesgo Vascular, Servicio de Medicina Interna, Sant Joan Despí Moisès Broggi-Hospital General Hospitalet, Consorci Sanitari Integral, Barcelona, España.
Insights
Malignant arterial hypertension remains a critical condition despite available treatments. Early detection and prompt antihypertensive therapy are vital for managing this life-threatening hypertensive emergency and preventing multi-organ failure.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Malignant arterial hypertension is a severe form of high blood pressure.
- Despite advances in antihypertensive drugs, this condition persists in clinical practice.
- It carries a high risk of mortality and poor prognosis if untreated.
Abstract:
Malignant arterial hypertension is still present in current clinical care despite the fact that for more than three decades we have had a wide range of antihypertensive drugs to control high blood pressure. It is essential to know how to detect it in time due to its high risk to life, with poor short-term prognosis if not treated properly. It may present with nonspecific, but potentially serious, clinical symptoms or manifest clinically as a hypertensive emergency accompanied by hypertensive encephalopathy and multi-organ failure. We present a case of a 49-year-old woman, attended in our hospital who had an initial hypertension of 223/170mmHg accompanied by multi-organ failure, who progressed satisfactorily with antihypertensive treatment.
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