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Updated: Jan 3, 2026
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Clinical Features and Expression Patterns for Burn Patients Developed Marjolin Ulcer
Dongyu Li1, Chenghao Hu2, Xing Yang2,3
1Department of Genetics and Medical Genetics, College of Agricultural and Life Science, University of Wisconsin - Madison.
Summary
Marjolin's ulcer, a skin cancer from chronic wounds, shows increased survivin protein expression. Higher survivin levels correlate with lymphatic metastasis, suggesting it as a therapeutic target.
Area of Science:
- Oncology
- Dermatology
- Molecular Biology
Background:
- Marjolin's ulcer is a rare skin malignancy developing from chronic non-healing wounds.
- The exact pathogenesis of Marjolin's ulcer remains poorly understood.
- Understanding disease mechanisms is crucial for improving patient outcomes.
Purpose of the Study:
- To retrospectively analyze cases of Marjolin's ulcer.
- To investigate the expression patterns and role of survivin in Marjolin's ulcer pathogenesis.
- To explore potential therapeutic targets for Marjolin's ulcer.
Main Methods:
- Retrospective analysis of patients diagnosed with Marjolin's ulcer between 2005 and 2019.
- Examination of survivin expression in Marjolin's ulcer tissues.
- Comparison of survivin expression between Marjolin's ulcer and simple skin ulcers.
- Correlation analysis between survivin expression, clinical characteristics, and lymphatic metastasis.
Main Results:
- The average latent period for Marjolin's ulcer development was 8.43 years (range: 2-25 years).
- Marjolin's ulcer occurred more frequently on extremities and joints.
- Survivin expression was significantly higher in Marjolin's ulcer compared to skin ulcers.
- Elevated survivin expression correlated significantly with lymphatic metastasis in Marjolin's ulcer patients.
Conclusions:
- Survivin is overexpressed in Marjolin's ulcer and is associated with lymphatic metastasis.
- Prompt diagnosis and management are essential due to poor prognosis in metastatic cases.
- Survivin represents a potential therapeutic target for Marjolin's ulcer treatment, aiming to improve efficacy and quality of life.
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