Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multitask Artificial Intelligence-Based Electrocardiogram Tool for Preoperative Cardiac Testing in Noncardiac Surgery: Retrospective Cohort Study of Health Care Utilization and Costs.

Journal of medical Internet research·2026
Same author

External validation of ECG artificial intelligence for emergency and cardiac assessment across a large-scale U.S. healthcare system.

NPJ digital medicine·2026
Same author

Detecting Erythrocyte-Derived Extracellular Vesicles Generated from Blood Pump Flow and the Challenges Encountered.

Cells·2026
Same author

Retinocortical in-sensor neuromorphic vision platform for NIR-augmented artificial vision.

Nature communications·2026
Same author

Integrating Task-Technology Fit and Community of Practice Theories to Enhance Medical Educator Skill Confidence in Generative AI: Design, Implementation, and Pilot Outcomes.

Medical science educator·2026
Same author

Validation of AI-enhanced ECG image analysis for identifying extreme cardiac magnetic resonance metrics in a cross-ethnic UK biobank study.

Scientific reports·2026

Related Experiment Video

Updated: Jan 3, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

9.0K

Development of a Cuvette-Based LSPR Sensor Chip Using a Plasmonically Active Transparent Strip.

Seo Yeong Oh1, Nam Su Heo1,2, Vivek K Bajpai3

  • 1Department of Biological Engineering, Inha University, Incheon, South Korea.

Frontiers in Bioengineering and Biotechnology
|November 19, 2019
PubMed
Summary

This study presents a new localized surface plasmon resonance (LSPR) biosensor for detecting C-reactive protein (CRP). The portable sensor chip achieves sensitive and reproducible CRP detection, with potential applications in diagnostics and monitoring.

Keywords:
C-reactive protein (CRP)localized surface plasmon resonance (LSPR)plasmon chipportable sensor chipself-assembly method

More Related Videos

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

12.4K
Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

1.9K

Related Experiment Videos

Last Updated: Jan 3, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

9.0K
Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

12.4K
Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

1.9K

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Localized Surface Plasmon Resonance (LSPR) biosensors offer high sensitivity for biomolecule detection.
  • Developing portable and cost-effective LSPR sensor chips is crucial for widespread diagnostics.
  • C-reactive protein (CRP) is a key biomarker for inflammation and cardiovascular disease.

Purpose of the Study:

  • To develop a transmission-mode LSPR sensor chip for sensitive C-reactive protein (CRP) detection.
  • To optimize the self-assembly process for creating a uniform, high-density layer of gold nanoparticles (AuNPs) on transparent substrates.
  • To integrate the optimized LSPR sensor chip into a cuvette cell system for portable application.

Main Methods:

  • Fabrication of LSPR sensor chip using self-assembled gold nanoparticles (AuNPs) on amine-functionalized substrates (APTES).
  • Optimization of substrate surface modification (0.5% APTES at 60°C) and AuNP decoration time (8 hours).
  • Functionalization of the plasmonic strip with anti-CRP antibodies and integration into a cuvette cell system.

Main Results:

  • Achieved a sensitive detection limit of 0.01 μg/mL for CRP.
  • Demonstrated a wide detection dynamic range of 0.01-10 μg/mL.
  • Confirmed excellent selectivity, reproducibility (%CV <10%), and stability of the LSPR biosensor.

Conclusions:

  • The developed portable LSPR biosensor provides a highly sensitive and reproducible platform for CRP detection.
  • The cuvette cell system enhances the practicality and portability of the LSPR sensor.
  • This technology holds significant potential for applications in clinical diagnostics, environmental monitoring, and food safety.