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Updated: Jan 3, 2026

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

The clipping enigma.

John C Lisko¹, Peter C Block¹

¹Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions

|November 19, 2019

Summary

This summary is machine-generated.

The MitraClip device, combined with optimal medical therapy (OMT), may reduce mortality and hospitalizations for heart conditions compared to OMT alone. However, evidence from randomized trials is limited and shows conflicting results.

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Area of Science:

Cardiology
Interventional Cardiology
Medical Devices

Background:

MitraClip therapy in conjunction with optimal medical therapy (OMT) is being evaluated for patients with heart conditions.
The primary focus is on comparing its efficacy against OMT alone.

Discussion:

Preliminary findings suggest a potential reduction in mortality and hospitalization rates for patients receiving MitraClip + OMT.
The existing evidence base relies on a small number of randomized controlled trials, which have yielded discordant results.

Key Insights:

MitraClip + OMT may offer improved outcomes regarding mortality and hospitalization compared to OMT alone.
The current evidence is limited, with only two randomized controlled trials available.

Outlook:

Further research with larger, well-designed randomized controlled trials is necessary to definitively establish the benefits of MitraClip + OMT.
Clarifying the discordant results from existing trials is crucial for clinical decision-making.