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Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Related Experiment Video

Updated: Jan 3, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Risk of Kidney Dysfunction IN Nafld.

Alessandro Mantovani1, Chiara Zusi1, Andrea Dalbeni2

  • 1Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

Current Pharmaceutical Design
|November 19, 2019
PubMed
Summary

Non-alcoholic fatty liver disease (NAFLD) is linked to an increased risk of chronic kidney disease (CKD). Regular monitoring of kidney function is recommended for NAFLD patients, and NAFLD should be considered in CKD patients.

Keywords:
CKDNAFLDNon-alcoholic fatty liver diseasechronic kidney diseasephospholipaserenal dysfunction.

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Area of Science:

  • Nephrology
  • Hepatology
  • Genetics

Background:

  • Chronic kidney disease (CKD) is a common systemic disease that increases the risk of end-stage renal disease and comorbidities.
  • Non-alcoholic fatty liver disease (NAFLD) is the most common chronic disease globally.
  • A potential link between NAFLD and CKD is an area of growing research interest.

Purpose of the Study:

  • To investigate the association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD).
  • To review existing literature on the relationship between NAFLD and CKD risk, prevalence, and progression.

Main Methods:

  • A systematic literature search was conducted using relevant keywords.
  • Included studies and meta-analyses investigating the NAFLD-CKD association.

Main Results:

  • Observational studies and meta-analyses suggest an independent association between NAFLD and CKD risk in diverse populations, including those with and without diabetes.
  • While the link to prevalent CKD is strong, the association with CKD development and progression remains under investigation.
  • Emerging evidence indicates a potential independent association between the PNPLA3 rs738409 genotype and reduced kidney function.

Conclusions:

  • There is convincing evidence that CKD is more prevalent in patients with NAFLD.
  • Patients with NAFLD require regular renal function monitoring.
  • NAFLD should be considered in the clinical evaluation of CKD patients, particularly those who are obese or have type 2 diabetes.