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Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases
Özcan Uzun1, Abdullah Bolu1, Azize Beril Taşçi2
1Department of Psychiatry, Gülhane Medical School.
Background:
Negative myoclonus is rarely seen in the clinical setting. It can be involved in some central nervous system pathologies. It has also been observed after antipsychotic treatment.
Case Reports:
In this article, we will present 3 cases diagnosed with negative myoclonus in a 120-bed university-affiliated hospital within the past 7 years. Based on our clinical experience, it was observed that myoclonic jerk was a rare condition that started with suddenly dose changes. Patients showed good improvement in response to dose reduction.
Conclusions:
Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose.
