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Identification of 33 novel HLA alleles in Arab potential bone marrow donors

Amal Bishara1, Chaim Brautbar1, Nezih Cereb2

  • 1Tissue Typing and Immunogenetics Laboratory, Hadassah Medical Center, Jerusalem, Israel.

HLA
|November 19, 2019
PubMed

Between 2008 and April 2018, we recruited more than 37 000 potential Arab donors to the Hadassah Bone Marrow Donor Registry, all of whom were typed for high resolution HLA-A, -B, and -DRB1. In addition, more than 22% of them were also typed for their HLA-C and -DQB1 alleles. A comparison of the sequences obtained from these donors with the IPD-IMGT/HLA Database showed 33 novel alleles from five loci (HLA-A, -B, -C, -DR, -DQ). All of these novel HLA alleles were detected in the local Arab communities; 79% of these alleles have not been described in other groups yet and remain unique to the local Arab communities.

Keywords:
ArabHLANGSnovel allelessequence

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