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Related Experiment Video

Updated: Jan 3, 2026

Separation of Plasmodium falciparum Late Stage-infected Erythrocytes by Magnetic Means

Separation of Plasmodium falciparum Late Stage-infected Erythrocytes by Magnetic Means

Published on: March 2, 2013

Portable Resource-Independent Blood-Plasma Separator.

S Vemulapati¹, D Erickson^1,2

¹Sibley School of Mechanical and Aerospace Engineering , Cornell University , Ithaca , New York 14853 , United States.

Analytical Chemistry

|November 19, 2019

Summary

This summary is machine-generated.

A novel magnetic bead-based sleeve offers efficient, resource-independent blood-plasma separation for field use. This High Efficiency Rapid Magnetic Erythrocyte Separator (H.E.R.M.E.S) sleeve overcomes limitations of traditional centrifuges in remote settings.

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Area of Science:

Biomedical Engineering
Medical Devices
Hematology

Background:

Centrifuges are standard for lab blood processing but impractical for field use due to power, size, and complexity.
Limited field-deployable solutions hinder remote blood sample collection in human and veterinary medicine.
A resource-independent method for efficient blood-plasma separation is needed for mobile practitioners.

Purpose of the Study:

To develop a portable, resource-independent device for efficient blood-plasma separation.
To introduce the High Efficiency Rapid Magnetic Erythrocyte Separator (H.E.R.M.E.S) sleeve for field sample processing.
To demonstrate the efficacy of magnetic bead-based separation in a novel sleeve format.

Main Methods:

Development of the H.E.R.M.E.S sleeve utilizing a magnetic bead-based separation assay.
Employing a unique mixing scheme for efficient erythrocyte separation from plasma.
Testing the sleeve with human blood samples up to 1 mL volume.

Main Results:

The H.E.R.M.E.S sleeve achieved highly efficient erythrocyte-plasma separation.
The device demonstrated ease of use and complete resource independence.
Performance was validated against conventional end-over-end mixing techniques.

Conclusions:

The H.E.R.M.E.S sleeve presents a viable, resource-independent alternative to centrifuges for field blood sample processing.
This technology can significantly improve remote blood collection capabilities for mobile medical practitioners.
The magnetic bead-based approach offers a scalable solution for efficient plasma separation in diverse settings.