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A Few Key Historical Events in the Antibody Field: The Alacritous Antibody

Ivan Lefkovits1

  • 1Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Viral Immunology
|November 19, 2019
PubMed

We have coined the term "alacrity" to describe the extraordinary diversity of B cell activation potentials, even among cells in a single B cell clone responding to a single antigen. The discovery of methodologies for B cell culture in limiting dilution allowed scientists to identify the source of cellular heterogeneity among cells of the immune system. Analyses of individual B cells set the stage for more detailed descriptions of the factors that diversify B cell functions, some of which will be expanded upon by partner articles in this B cell issue.

Keywords:
B cell immunologyantibodylimiting dilution“alacrity,”

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