Related Experiment Video
Updated: Jan 3, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Q Fever and Kingella kingae Endocarditis in a Toddler: A Rare Coinfection Case
Shelly Kagan1, Itzhak Levy2,3, Liat Ashkenazi-Hoffnung1,2,3
1From the Department of Pediatrics B.
Insights
A toddler with a history of tetralogy of Fallot repair developed endocarditis caused by Kingella kingae and Coxiella burnetii coinfection. This rare dual infection required both medical and surgical treatment.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
- Microbiology
Background:
- Tetralogy of Fallot repair in infancy can predispose patients to cardiac complications.
- Endocarditis is a serious infection of the heart lining or valves.
- Coinfections present diagnostic and therapeutic challenges.
Observation:
- A toddler, post-tetralogy of Fallot graft repair, presented with endocarditis.
- Blood cultures identified Kingella kingae, and serology indicated Coxiella burnetii infection.
- A postoperative specimen confirmed the coinfection via polymerase chain reaction.
Findings:
- The patient had a confirmed coinfection with Kingella kingae and Coxiella burnetii.
- The infection occurred in a young child with a history of congenital heart disease repair.
- Combined medical and surgical interventions were necessary for treatment.
Implications:
- Highlights the possibility of rare coinfections in pediatric endocarditis.
- Emphasizes the importance of thorough patient history in diagnosing unusual pathogens.
- Suggests vigilance for atypical pathogens in immunocompromised or post-surgical patients.
Abstract:
A toddler after tetralogy of Fallot graft repair in infancy was diagnosed with endocarditis. Blood cultures were positive for Kingella kingae and serology was positive Coxiella burnetii. He was treated medically and surgically. A postoperative specimen polymerase chain reaction confirmed a coinfection. A comprehensive patient history was imperative for identification of an unlikely infection at this age.
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis I: Introduction
Endocarditis III: Medical Management
Endocarditis IV: Nursing Management
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:

