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Scaffold-based tissue engineering approaches in treating infertility.
Yalda Jahanbani1, Soudabe Davaran2, Maryam Ghahremani-Nasab2
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Life Sciences
|November 19, 2019
Summary
Tissue engineering scaffolds offer promising treatments for male and female infertility caused by various factors. Stem cell-based approaches using scaffolds are being explored to overcome limitations of patient-derived cells for fertility restoration.
Area of Science:
- Regenerative Medicine
- Reproductive Biology
Background:
- Infertility affects many couples globally, stemming from causes like chemotherapy, uterine injuries, and adhesions.
- Tissue engineering utilizes extracellular matrix scaffolds as substrates for cell implantation and growth, showing therapeutic potential.
Purpose of the Study:
- To review novel scaffold-based tissue engineering strategies for treating male and female infertility.
- To explore the use of stem cells as an alternative to patient-derived cells in fertility treatments.
Main Methods:
- Review of current literature on scaffold-based tissue engineering for infertility.
- Discussion of cell/scaffold systems for fertility organ repair and regeneration.
- Evaluation of stem cell sources like embryonic stem cells and mesenchymal stem cells.
Main Results:
- Scaffold-based tissue engineering demonstrates significant potential for infertility treatment.
- Patient-derived cells have limitations including invasiveness and potential disease transmission.
- Stem cells (ESCs, BM-MSCs, UC-MSCs) offer a promising alternative for cell/scaffold systems.
Conclusions:
- Scaffold-based tissue engineering, particularly with stem cells, presents a viable approach to address infertility.
- These methods hold promise for the repair and regeneration of reproductive organs.
- Further research into cell/scaffold systems can advance infertility therapeutics.
