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Telomerase-specific attenuated viruses, a definitive strategy or just one more in circulating tumor cells detection

Elena Soria1, Miren Vallejo1, Luis Saenz2

  • 1Oncohematology Research Group, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Irunlarrea 3, 31008, Pamplona, Spain.

Cancer Letters
|November 19, 2019
PubMed

Insights

Detecting circulating tumor cells (CTCs) is challenging due to a lack of universal markers. Telomerase-specific replication-selective viruses offer a novel approach to identify and quantify these cancer cells for improved diagnosis and prognosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Circulating Tumor Cells (CTCs) detection and isolation are critical in cancer research.
  • Current methods face limitations in detecting the complete CTC population due to a lack of universal markers.
  • Telomerase activity, a characteristic of most tumor cells, presents a potential target for CTC identification.

Purpose of the Study:

  • To review the scientific literature on Telomerase-specific replication-selective viruses for CTC detection.
  • To explore the application of this technology in cancer diagnosis and prognosis.

Main Methods:

  • Review of published scientific studies utilizing Telomerase-specific replication-selective viruses.
  • Analysis of the role of these viruses in identifying CTCs based on telomerase activity.

Main Results:

  • Telomerase-specific replication-selective viruses have emerged as a promising tool for CTC identification.
  • This technology leverages the loss of telomerase inactivation in tumor cells.
  • The review consolidates existing research on this advanced molecular tool.

Conclusions:

  • Telomerase-specific replication-selective viruses represent an advanced technology for CTC detection.
  • These viruses show potential in improving cancer diagnosis and patient prognosis.
  • Further research and application of this technology are warranted in clinical settings.
Keywords:
Gene engineeringLiquid biopsyQuantification of circulating cancer cellsReplication-selective tumor-specific virusesTumor dissemination

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