Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-flow nasal oxygen for the relief of persistent dyspnea in adult patients with cancer: A systematic review and meta-analysis.

Palliative medicine·2026

Same author

Dyspnoea patterns in patients with advanced diseases: a functional MRI feasibility study protocol.

BMJ open·2026

Same author

Description of three dysfunctional breathing patterns in post-COVID dyspnea.

Respiratory physiology & neurobiology·2026

Same author

[Hypnosis and pulmonology : a complementary approach].

Revue medicale suisse·2025

Same author

An objective method to detect sighs during cardio-pulmonary exercise testing.

Scientific reports·2025

Same author

Predictability of breathing parameters during cardiopulmonary exercise testing using entropy measurements.

Physiological reports·2025

Same journal

Revue medicale suisse·2026

Same journal

Revue medicale suisse·2026

Same journal

Revue medicale suisse·2026

Same journal

Revue medicale suisse·2026

Same journal

Revue medicale suisse·2026

Same journal

[Erythema multiforme : target deciphering].

Revue medicale suisse·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 3, 2026

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

[COPD and phenotypes].

Ivan Guerreiro¹, Paola M Soccal¹

¹Service de pneumologie, Département de médecine, HUG, 1211 Genève 14.

Revue Medicale Suisse

|November 20, 2019

Summary

This summary is machine-generated.

Understanding Chronic Obstructive Pulmonary Disease (COPD) phenotypes is crucial for targeted treatments. Key factors include lung function, exacerbations, eosinophilia, and cardiovascular comorbidities, aiding disease management.

More Related Videos

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Related Experiment Videos

Last Updated: Jan 3, 2026

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Area of Science:

Pulmonary Medicine
Respiratory Disease Research

Background:

Chronic Obstructive Pulmonary Disease (COPD) is a complex respiratory condition with varied patient presentations.
Effective phenotyping, crucial for guiding treatment and clinical management, remains less standardized compared to asthma.

Purpose of the Study:

To elucidate the essential components of COPD phenotyping.
To emphasize the role of lung function, exacerbations, biomarkers, and comorbidities in classifying COPD.

Main Methods:

Review of recent studies, primarily from the ECLIPSE and SPIROMICS cohorts.
Analysis of key factors including lung function, exacerbation history, biomarker assessment (e.g., eosinophilia), and cardiovascular comorbidities.

Main Results:

Phenotyping COPD aids in understanding disease progression and exacerbations.
Identifying eosinophilia and assessing cardiovascular comorbidities are highlighted as critical elements in current COPD phenotyping strategies.

Conclusions:

Accurate COPD phenotyping is essential for personalized medicine approaches.
Integrating lung function, exacerbation data, biomarkers, and comorbidities improves clinical work-up and treatment targeting for COPD patients.