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Phase angle as a severity indicator for liver diseases
Ana Paula Pagano1, Juliana Maria Faccioli Sicchieri1, Isabela Laurencio Schiavoni1
1Hospital of Clinics, School of Medicine of Ribeirão Preto, Department of Internal Medicine, Division of Nutrition and Metabolism, University of São Paulo, Brazil.
Nutrition (Burbank, Los Angeles County, Calif.)
|November 20, 2019
Summary
Phase angle (PhA) shows promise as a severity indicator for chronic liver diseases like hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD). This study suggests PhA is an independent prognostic indicator for cirrhosis and may impact patient survival.
Area of Science:
- Hepatology and Gastroenterology
- Nutritional Science
- Biomarker Research
Background:
- Chronic liver diseases, including hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD), significantly impact patient health and prognosis.
- Assessing disease severity and nutritional status is crucial for effective management and predicting patient outcomes.
- Phase angle (PhA), a parameter derived from bioelectrical impedance analysis (BIA), has emerged as a potential indicator of cellular integrity and nutritional status.
Purpose of the Study:
- To evaluate the clinical applicability of phase angle (PhA) as a severity indicator in patients with chronic liver diseases.
- To investigate the correlation between PhA and established clinical severity scores (Child-Pugh, BCLC, APRI, FIB-4) in HCC and NAFLD patients.
- To explore the relationship between PhA and nutritional parameters, and its potential as a prognostic indicator for survival.
Main Methods:
- Retrospective analysis of medical records from 54 patients (27 HCC, 27 NAFLD) aged 18 years and above.
- Collection of clinical data including severity scores (Child-Pugh, BCLC, APRI, FIB-4), nutritional parameters (BMI, HGS, BIA data), and Nutritional Risk Index (NRI).
- Statistical analysis using Mann-Whitney test, ANOVA, multiple linear regression, ROC curve analysis, and Kaplan-Meier survival estimation.
Main Results:
- While no patients were undernourished by BMI, 74.1% of HCC patients showed nutritional risk via NRI.
- Child-Pugh scores correlated positively with edema index (ECW/TBW) and negatively with PhA and HGS.
- A trend towards lower survival was observed in HCC patients with PhA below 5.1 degrees, suggesting PhA's prognostic value.
Conclusions:
- Phase angle (PhA) is a potential independent prognostic indicator for cirrhosis in chronic liver disease patients.
- PhA may be associated with patient survival, particularly in hepatocellular carcinoma.
- Further research is warranted to fully elucidate the role of PhA in managing and predicting outcomes for chronic liver diseases.
Keywords:
Bioeletrical impedanceChronic liver diseasesHandgrip strengthNutritional Risk IndexPhase angleMore Related Videos
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