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Poikilodermatous mycosis fungoides with CD30-positive large cell transformation successfully treated by brentuximab
Svetlana Popadic1,2, Branislav Lekic1, Srdjan Tanasilovic1,2
1Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia.
Abstract:
We present a patient with a 33-year history of poikilodermatous mycosis fungoides (MF) who subsequently developed CD30-positive large cell transformation. After 6 years of conventional MF treatment, side effects of therapy and/or concomitant diseases prevented the previously applied treatment modalities. The CD30-directed antibody-cytotoxic drug conjugate (brentuximab vedotin) was introduced and followed by quick and excellent therapeutic response.
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