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DoseCal: a virtual calculator for dosage conversion between human and different animal species
P Janhavi1,2, S Divyashree1, K P Sanjailal3
1Department of Biochemistry, CSIR Central Food Technological Research Institute, Mysore, India.
Archives of Physiology and Biochemistry
|November 21, 2019
Summary
Accurate drug dosage conversion between species is crucial for pharmacology. A new calculator, DoseCal, uses the Km factor for precise human and animal dose calculations, preventing errors.
Area of Science:
- Pharmacology and Drug Development
- Computational Biology
- Veterinary Medicine
Background:
- Accurate dose conversion between human and animal species is essential in pharmacology.
- Simple body weight-based extrapolation for drug dosage is often inaccurate.
- Dosage miscalculations can lead to adverse effects or reduced drug efficacy.
Purpose of the Study:
- To develop a reliable dose conversion calculator incorporating the Km factor.
- To create a tool that facilitates accurate drug dosage extrapolation across species.
Main Methods:
- A web-based application named DoseCal was developed using hypertext pre-processor programming language.
- MySQL software was utilized for data management within the DoseCal application.
Main Results:
- DoseCal was successfully developed, utilizing the Km factor for dose conversion.
- The calculator provides accurate dosage information based on both per kg and actual animal weight.
Conclusions:
- DoseCal offers an easy and accurate solution for scientists performing interspecies drug dosage conversions.
- The tool aids in preventing dosage errors, ensuring optimal drug efficacy and safety.
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