Related Experiment Video
Updated: Aug 14, 2026
12:44
The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
26.2K
Trichoblastic Carcinosarcoma Arising From the Vagina: A Case Report With Comprehensive Immunophenotypic Analysis
Joshua Jing Xi Li1, Joanna Ka Man Ng1, Paul Cheung Lung Choi1
1Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
International Journal of Surgical Pathology
|November 22, 2019
Summary
A rare vaginal carcinosarcoma, resembling cutaneous trichoblastic carcinoma, was identified in a 54-year-old woman. This unique case, confirmed by specific markers, showed favorable early outcomes after surgical removal.
Area of Science:
- Gynecologic Oncology
- Surgical Pathology
- Dermatopathology
Background:
- Carcinosarcomas are aggressive malignancies often arising in the uterus.
- Vaginal carcinosarcomas are exceedingly rare, with limited data on their specific subtypes and behavior.
Observation:
- A 54-year-old woman presented with abdominal pain due to an upper vaginal mass.
- Imaging revealed a localized mass without nodal or distant metastasis.
- Histological examination identified a trichoblastic carcinoma with sarcomatous and carcinomatous elements.
Findings:
- The tumor exhibited hair follicle differentiation, confirmed by positive staining for Bcl-2, TLE1, CD56/NCAM, and TDAG51.
- A CD10-positive trichogenic stroma was present.
- The tumor was classified as International Federation of Gynecology and Obstetrics (FIGO) stage I, confined to the vaginal muscularis, and completely excised with clear margins.
Implications:
- This is the first reported case of a vaginal carcinosarcoma with cutaneous-type trichoblastic differentiation.
- The distinct histology and immunophenotype suggest a different origin and behavior compared to typical gynecologic carcinosarcomas.
- Early disease-free survival highlights the potential for successful surgical management of this rare entity.
