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High intensity light exposure increases blood-brain barrier transport in rats
A Saija1, P Princi, R De Pasquale
1Dipartimento Farmaco-Biologico, School of Pharmacy, University of Messina, Italy.
Pharmacological Research Communications
|July 1, 1988
Abstract:
A quantitative technique utilizing 14C-alpha-aminoisobutyric acid as a tracer was used to study the blood-brain barrier permeability modifications induced by environmental stimuli, as the high intensity light exposure. The blood-to-brain transfer constant was significantly increased only in the occipital cortex following the treatment. The possibility that the blood-brain barrier is able to modify its local characteristics in response to cerebral activity changes was discussed.