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Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
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Early oral colostrum administration in preterm infants

Diana Maffei1, Mariana Brewer2, Champa Codipilly2

  • 1Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, Lilling Family Neonatal Research Lab, Feinstein Institutes for Medical Research, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, Hempstead, NY, USA. dmaffei@northwell.edu.

Journal of Perinatology : Official Journal of the California Perinatal Association
|November 22, 2019
PubMed

Insights

Early oral colostrum (OC) administration boosts immune components in preterm infants. Syringe delivery and higher doses enhance absorption of secretory IgA (sIgA) and lactoferrin, promoting a healthier microbiome.

Area of Science:

  • Neonatal immunology
  • Gastroenterology
  • Microbiome research

Background:

  • Oral colostrum (OC) may offer immune benefits to preterm infants.
  • Prior research on OC effects is limited by concurrent enteral feeding.

Purpose of the Study:

  • To measure oral colostrum absorption in preterm infants before enteral feeding.
  • Quantify absorption via urinary secretory IgA (sIgA) and lactoferrin levels.

Main Methods:

  • Colostrum collected from mothers of infants born at or before 32 weeks gestation or weighing ≤1500g.
  • Urinary sIgA and lactoferrin measured; microflora analyzed in saliva and tracheal aspirates.

Main Results:

  • Infants receiving OC via syringe showed significantly higher urinary sIgA and lactoferrin than those receiving it via swab (p<0.002).
  • Urinary sIgA levels positively correlated with the cumulative dose over 72 hours (R²=43%, p<0.01).

Conclusions:

  • Syringe administration and increased cumulative doses of OC enhance sIgA and lactoferrin absorption.
  • Early OC dosing may promote a more diverse tracheal microbiome in preterm infants.
Abstract

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