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Malignant Cutaneous Melanoma: Updates in PET Imaging
Riccardo Laudicella1, Lucia Baratto2, Fabio Minutoli1
1Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina ME, Italy.
Current Radiopharmaceuticals
|November 22, 2019
Summary
Advancements in nuclear medicine, specifically 18F-FDG PET/CT, improve melanoma imaging. Digital PET scanners offer enhanced sensitivity for detecting small lesions, potentially improving patient outcomes.
Area of Science:
- Nuclear Medicine
- Oncology Imaging
- Medical Physics
Background:
- Cutaneous malignant melanoma incidence and mortality are rising.
- 18F-FDG PET/CT is established for melanoma evaluation (metastases, recurrence, therapy response).
Purpose of the Study:
- To review nuclear medicine advancements for melanoma imaging.
- Focus on 18F-FDG PET technology and innovations.
Main Methods:
- Comprehensive literature search of SCOPUS and PubMed.
- Selected English articles on 18F-FDG PET technological insights in melanoma.
Main Results:
- Modern digital PET/CT scanners (silicon photomultiplier detectors) offer technical innovations.
- Detector design, software, and hardware (TOF, PSF) improve image quality, reduce dose, and shorten scan times.
Conclusions:
- Digital PET/CT and PET/MRI offer higher sensitivity than analog systems.
- Enables detection of smaller lesions, potentially impacting melanoma patient outcomes.

