Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid profile with eslicarbazepine acetate and carbamazepine monotherapy in adult patients with newly diagnosed focal seizures: <i>post hoc</i> analysis of a phase III trial and open-label extension study.

Therapeutic advances in neurological disorders·2023
Same author

Prevalence of Subclinical Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease: Analysis of the Paracelsus 10,000 Cohort Study.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2023
Same author

Network topology in brain tumor patients with and without structural epilepsy: a prospective MEG study.

Therapeutic advances in neurological disorders·2023
Same author

Acute symptomatic status epilepticus: Splitting or lumping? A proposal of classification based on real-world data.

Epilepsia·2023
Same author

How much refractory is 'refractory status epilepticus'? A retrospective study of treatment strategies and clinical outcomes.

Journal of neurology·2023
Same author

Relationships between education and non-alcoholic fatty liver disease.

European journal of internal medicine·2023

Related Experiment Video

Updated: Jan 3, 2026

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
06:58

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

Published on: June 25, 2016

19.9K

Repetitive miniature spikes - An underreported EEG pattern.

Iris Unterberger1, Peter W Kaplan2, Gerhard Luef1

  • 1Department of Neurology, Innsbruck, Medical University, Innsbruck, Austria.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|November 22, 2019
PubMed
Summary

Low-voltage repetitive spikes (RMS) are rare EEG patterns indicating focal epilepsy. Observing RMS on routine scalp EEGs suggests underlying structural brain pathology, prompting further investigation.

Keywords:
Epileptic seizuresEpileptiform dischargesFocal cortical dysplasiaRepetitive miniature spikes

More Related Videos

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

737
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

15.3K

Related Experiment Videos

Last Updated: Jan 3, 2026

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
06:58

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

Published on: June 25, 2016

19.9K
Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

737
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

15.3K

Area of Science:

  • Neuroscience
  • Clinical Electrophysiology

Background:

  • Low-voltage repetitive spikes (RMS) are typically associated with invasive EEG recordings and focal cortical dysplasia (FCD).
  • This specific EEG pattern has been underrepresented in routine scalp EEG literature.

Purpose of the Study:

  • To analyze the patterns of low-voltage repetitive spikes (RMS) on routine scalp EEG.
  • To investigate the association between RMS and clinical/brain imaging data.

Main Methods:

  • Prospective collection of scalp EEG recordings with RMS ( <50 µV) from 1982-2017.
  • Analysis of RMS patterns (rhythmic, periodic, irregular) and correlation with epilepsy, non-convulsive status epilepticus, and cerebral MRI findings.

Main Results:

  • RMS were observed in 38 patients, predominantly with frontal and central patterns.
  • A significant association was found with focal epilepsy (33/38 patients), including non-convulsive status epilepticus (11 patients).
  • Cerebral MRI revealed malformations of cortical development in 11 patients, with six diagnosed with FCD.

Conclusions:

  • Low-voltage repetitive spikes (RMS) are rare but significant EEG patterns indicative of focal epilepsy.
  • The presence of RMS on routine scalp EEG warrants further clinical and radiological investigation for underlying structural brain abnormalities like FCD.