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Does depressed persons with non-cardiovascular morbidity have a higher risk of CVD? A population-based cohort study

Aysha Almas1,2, Jette Moller3, Romaina Iqbal4

  • 1Department of Public Health Sciences, Karolinska Institutet, Widerströmska huset, 3rd floor, Tomtebodavägen 18 A, 171 77, Stockholm, Sweden. aysha.almas@aku.edu.

BMC Cardiovascular Disorders
|November 23, 2019
PubMed

Insights

Depression combined with other health problems significantly elevates the risk of cardiovascular disease (CVD). This comorbidity poses a greater future CVD risk than either condition alone.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Depression frequently co-occurs with non-cardiovascular conditions.
  • The impact of this comorbidity on cardiovascular disease (CVD) risk is not well-established.
  • Understanding this interaction is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate whether non-cardiovascular morbidity modifies the association between depression and future CVD risk.
  • To quantify the combined effect of depression and non-cardiovascular morbidity on CVD incidence.

Main Methods:

  • Utilized data from the longitudinal PART study (Mental Health, Work and Relationships).
  • Included 10,443 adults aged 20-64 years.
  • Assessed depression via Major Depression Inventory (MDI), non-cardiovascular morbidity via self-report, and CVD outcomes via the National Patient Register.

Main Results:

  • Both depression (HR 1.5) and non-cardiovascular morbidity (HR 2.0) independently increased future CVD risk.
  • The combination of depression and non-cardiovascular morbidity showed a significantly higher risk (HR 2.1) for future CVD.
  • These associations remained significant after adjusting for demographics, socioeconomic status, hypertension, diabetes, and lifestyle factors.

Conclusions:

  • Individuals with both depression and non-cardiovascular morbidity face a substantially elevated risk of developing cardiovascular disease.
  • This highlights the importance of addressing comorbid conditions in managing depression to mitigate cardiovascular risks.
Abstract

Keywords:
Cardiovascular diseasesDepressionMorbidityNon-cardiovascular morbidity

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