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Complete Genome Sequence of Proteus mirabilis Phage Myduc
Jennifer Tran1, Lauren Lessor1, Chandler O'Leary1
1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.
Microbiology Resource Announcements
|November 23, 2019
Summary
The genome of Myduc, a Proteus mirabilis myophage, was sequenced. This phage is related to Enterobacteria phage phiEcoM-GJ1 and has a small genome with T7-like RNA polymerase.
Area of Science:
- Microbiology
- Genomics
- Virology
Background:
- Proteus mirabilis is a significant nosocomial pathogen.
- Proteus mirabilis frequently causes urinary tract infections.
- Bacteriophages (phages) are viruses that infect bacteria and can be used in phage therapy.
Purpose of the Study:
- To describe the complete genome sequence of the P. mirabilis myophage, Myduc.
- To characterize Myduc's genomic features and its phylogenetic relationship to other phages.
Main Methods:
- Whole-genome sequencing of Myduc.
- Bioinformatic analysis of the genome sequence.
- Phylogenetic analysis to determine Myduc's relationship to known phages.
Main Results:
- The complete genome sequence of Myduc was determined.
- Myduc possesses a small genome size (52,000 to 56,000 bp).
- Myduc is phylogenetically related to Enterobacteria phage phiEcoM-GJ1 and features a T7-like RNA polymerase.
Conclusions:
- The genome sequence of Myduc provides valuable insights into P. mirabilis phages.
- Myduc's genomic characteristics suggest potential applications in phage therapy or diagnostics.
- Further research into Myduc's biological properties is warranted.
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