Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

218
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
218
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
Cancer Therapies02:49

Cancer Therapies

9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

762
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
762
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

634
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
634

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistance Exercise: A Potential Intervention for Managing Cardiovascular Health in Individuals with a History of Cancer.

Sports medicine - open·2026
Same author

Three-Point Correction Factor Improves Accuracy of Framingham Risk Score in Breast Cancer Survivors.

The Canadian journal of cardiology·2026
Same author

Women's Midlife: A Nexus of Depression, Insulin Resistance, and Opportunity for Lifestyle Intervention.

Journal of women's health (2002)·2025
Same author

Reference Values for Water-Specific T1, Intermuscular and Intramuscular Fat Content in Skeletal Muscle at 2.89 T.

Journal of magnetic resonance imaging : JMRI·2025
Same author

Digital Intervention for behaviouR changE and Chronic disease prevenTION (DIRECTION): Study protocol for a randomized controlled trial of a web-based platform integrating nutrition, physical activity, and mindfulness for individuals with obesity.

Methods (San Diego, Calif.)·2024
Same author

Evaluating predictive equations for energy requirements throughout breast cancer trajectory: A comparative study.

Clinical nutrition (Edinburgh, Scotland)·2024
Same journal

Target trial emulation studies in oncology: a comprehensive analysis.

The oncologist·2026
Same journal

Durable Response to Sotorasib in KRAS G12C-Mutant Intrahepatic Cholangiocarcinoma: A Case Report.

The oncologist·2026
Same journal

The Impact of Relative Dose Intensity on pCR in Neoadjuvant Chemotherapy of Muscle-Invasive Urothelial Cancer: a Multicentre Retrospective Study.

The oncologist·2026
Same journal

Prevalence, treatment and survival of Malignant Peripheral Nerve Sheath Tumor in the Danish neurofibromatosis type 1 population.

The oncologist·2026
Same journal

Molecular Tumor Board-Guided Osimertinib Therapy in EGFR L858R/Q701L-Mutant Lung Adenocarcinoma Supported by Functional Validation.

The oncologist·2026
Same journal

Phase 2 Dose Expansion Trial of OBI-3424, a DNA-Alkylating Prodrug, in Patients with Advanced Solid Tumors Expressing AKR1C3.

The oncologist·2026
See all related articles

Related Experiment Video

Updated: Jan 3, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

10.2K

Supervised, Multimodal Exercise: The Chemotherapy Supportive Therapy That Almost Does It All.

Amy A Kirkham1

  • 1Department of Biomedical Engineering, University of Alberta, Edmonton, Canada.

The Oncologist
|November 23, 2019
PubMed
Summary
This summary is machine-generated.

The OptiTrain trial evaluated exercise interventions to improve chemotherapy completion and reduce hospitalizations. Results provide context for optimizing cancer patient care through exercise.

Keywords:
Breast neoplasmsDrug therapyExercise therapyTreatment adherence and compliance

More Related Videos

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
05:44

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

10.5K
Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.4K

Related Experiment Videos

Last Updated: Jan 3, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

10.2K
Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
05:44

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

10.5K
Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.4K

Area of Science:

  • Oncology
  • Exercise Science
  • Clinical Trials

Background:

  • Cancer patients undergoing chemotherapy often experience treatment delays and adverse events.
  • Chemotherapy completion is crucial for treatment efficacy and patient outcomes.
  • Exercise interventions are being explored to mitigate treatment toxicity and improve adherence.

Purpose of the Study:

  • To provide context and interpretation for the findings of the OptiTrain randomized trial.
  • To discuss the impact of exercise interventions on chemotherapy completion rates.
  • To analyze the effects of exercise on hospitalization and hematological toxicity in cancer patients.

Main Methods:

  • The OptiTrain trial was a three-arm randomized controlled trial.
  • It compared two distinct exercise interventions against usual care.
  • Outcomes assessed included chemotherapy completion, hospitalization rates, and hematological toxicity.

Main Results:

  • The commentary contextualizes the OptiTrain trial's findings regarding exercise and chemotherapy outcomes.
  • It highlights the potential benefits of specific exercise regimens.
  • The discussion places the trial's results within the broader landscape of supportive cancer care.

Conclusions:

  • Exercise interventions show promise in improving the tolerability and completion of chemotherapy.
  • Further research and clinical integration of exercise are warranted.
  • Optimizing supportive care through exercise can enhance patient management during cancer treatment.