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[Respiratory effects of nicotine and naloxone]
J Jiménez-Vargas1, S Fernández-González, S Dawid-Milner
1Dpto. de Fisiologia, Facultad de Medicina, Universidad de Navarra, Pamplona.
Revista De Medicina De La Universidad De Navarra
|January 1, 1988
Abstract:
The effect of an i.v. bolus injection of nicotine 50 micrograms/kg-1, was compared in 6 awake dogs with the effect of nicotine injection after naloxone, 400 micrograms/kg-1. Respiratory inhibition was produced immediately after beginning the nicotine injection, followed by hyperpnea. Naloxone produced a significant decrease of the respiratory inhibition followed by hyperpnea increase compared to the trial with only nicotine.