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Acute alcoholic intoxication and naloxone. Effects on visual evoked potential
M S Dawid-Milner1, E J Díaz-Calavia, R Fernández del Moral
1Departamento de Fisiología, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Revista Espanola De Fisiologia
|June 1, 1992
Summary
Naloxone amplifies alcohol
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Alcohol intoxication affects brain function.
- Visual evoked potentials (VEPs) measure visual pathway activity.
Purpose of the Study:
- To investigate the effects of naloxone on alcohol-induced VEP changes.
- To understand how naloxone modulates alcohol's impact on the visual system.
Main Methods:
- Cats received continuous intravenous ethanol infusion.
- One group was pre-treated with intravenous naloxone before ethanol.
- VEP parameters were analyzed during intoxication.
Main Results:
- Ethanol altered VEP parameters.
- Naloxone pre-treatment potentiated alcohol's effects on VEPs.
- Naloxone increased the incidence of isoelectric postpotentials and flat VEPs.
Conclusions:
- Naloxone enhances the neurotoxic effects of acute alcohol intoxication on the visual pathway.
- This suggests an interaction between naloxone and ethanol in the central nervous system.