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Isolation of Murine Embryonic Hemogenic Endothelial Cells
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Vancomycin Spacer-induced Hemolysis.

Anuraj Sudhakaran1, Aparna Baburaj2, Kinjal Banerjee1

  • 1Internal Medicine, Geisinger Medical Center, Danville, USA.

Cureus
|November 23, 2019
PubMed
Summary
This summary is machine-generated.

Vancomycin-induced hemolysis can occur, potentially due to additives. A case showed hemolysis resolved after removing a vancomycin spacer, suggesting a link beyond standard intravenous administration.

Keywords:
auto immune hemolytic anemiadrug induced hemolysisdrug induced hemolytic anemiahemolysis after orthopedic procedurespacer induced hemolysisvancomycin induced hemolysis

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Area of Science:

  • Pharmacology
  • Hematology
  • Infectious Diseases

Background:

  • Intravenous vancomycin is a critical antibiotic for treating serious infections.
  • Hemolysis, a condition of red blood cell destruction, has been linked to vancomycin therapy.
  • This adverse effect is often attributed to antibodies against excipients in vancomycin formulations.

Observation:

  • A 72-year-old male patient developed hemolysis.
  • The hemolysis occurred subsequent to the placement of a vancomycin spacer.
  • Symptoms of hemolysis improved significantly after the removal of the vancomycin spacer.

Findings:

  • The patient's hemolysis was directly associated with the presence of a vancomycin spacer.
  • Removal of the vancomycin spacer led to the resolution of hemolytic anemia.
  • This case suggests vancomycin spacers themselves, or their interaction within the localized environment, can induce hemolysis.

Implications:

  • Vancomycin spacers may represent an underrecognized cause of drug-induced hemolysis.
  • Clinicians should consider vancomycin spacers in the differential diagnosis of hemolysis in patients receiving them.
  • Further investigation into the mechanisms of vancomycin spacer-induced hemolysis is warranted.