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Updated: Jul 4, 2026
03:05
Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
A Prospective Case-Control Study of Helicobacter pylori and Systemic Inflammation in Colorectal Cancer Pathogenesis
Imad Sibhai1, Mounika Kotte2, Abubakar Gapizov3
1Medical Education, Smt. Nathiba Hargovandas Lakhmichand (NHL) Municipal Medical College, Ahmedabad, IND.
Cureus
|July 3, 2026
Summary
High neutrophil-to-lymphocyte ratio (NLR) strongly predicts colorectal cancer (CRC) risk in Pakistan. Active Helicobacter pylori infection showed no direct link, but interacted with NLR, suggesting inflammation modifies H. pylori effects. Further research is needed.
Area of Science:
- Gastroenterology and Oncology
- Inflammation and Carcinogenesis
Background:
- The association between Helicobacter pylori (H. pylori) infection and colorectal cancer (CRC) remains debated.
- Systemic inflammation is recognized as a driver of carcinogenesis.
- This study investigates H. pylori and neutrophil-to-lymphocyte ratio (NLR) in CRC risk.
Purpose of the Study:
- To assess the independent and interactive associations of active H. pylori infection and NLR with CRC risk.
- To evaluate H. pylori's role in CRC within a Pakistani cohort.
- To explore NLR as a potential biomarker for CRC risk stratification.
Main Methods:
- Prospective case-control study involving 105 CRC patients and 210 controls.
- Active H. pylori infection diagnosed via stool antigen testing.
- NLR dichotomized at the median (2.5) and analyzed using multivariate logistic regression.
Main Results:
- No significant difference in H. pylori prevalence between CRC cases and controls.
- High NLR (>2.5) was significantly associated with increased CRC risk (aOR = 300.86).
- A significant negative interaction was found between H. pylori and high NLR (aOR = 0.245).
Conclusions:
- Elevated NLR is a strong predictor of CRC in this Pakistani cohort.
- Active H. pylori infection did not show a direct association with CRC.
- Host inflammatory status, indicated by NLR, may modify H. pylori's impact on CRC; larger studies are required for confirmation.
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