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Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
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Lactate dehydrogenase in dermatology practice.

A Livesey1, F Garty1, A R Shipman1

  • 1Dermatology Department, St Mary's Hospital, Portsmouth, UK.

Clinical and Experimental Dermatology
|November 23, 2019
PubMed
Summary

Lactate dehydrogenase (LDH) is a key prognostic marker in dermatology for cutaneous lymphoma. Elevated LDH levels, caused by cell damage, are reviewed alongside diagnostic and staging guidelines for this cancer.

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Area of Science:

  • Biochemistry
  • Oncology
  • Dermatology

Background:

  • Lactate dehydrogenase (LDH) is an intracellular enzyme central to anaerobic glycolysis.
  • LDH is ubiquitously expressed, with cell damage leading to its release into circulation.
  • Elevated LDH levels have multiple potential causes, necessitating careful interpretation.

Purpose of the Study:

  • To review the utility of lactate dehydrogenase (LDH) in dermatological practice.
  • To highlight LDH's role as a prognostic marker for cutaneous lymphoma.
  • To discuss current diagnostic and staging guidelines relevant to LDH.

Main Methods:

  • Literature review of studies on lactate dehydrogenase (LDH) in dermatology.
  • Analysis of LDH's role in anaerobic glycolysis and cellular damage.
  • Examination of diagnostic and staging protocols for cutaneous lymphoma.

Main Results:

  • Lactate dehydrogenase (LDH) serves as a significant prognostic indicator for cutaneous lymphoma.
  • Understanding LDH's origin from cell damage is crucial for interpreting elevated levels.
  • Current guidelines incorporate LDH in the assessment of cutaneous lymphoma.

Conclusions:

  • Lactate dehydrogenase (LDH) is a valuable marker in dermatology, especially for cutaneous lymphoma prognosis.
  • The interpretation of LDH levels requires consideration of its multiple causes.
  • Adherence to diagnostic and staging guidelines is essential for effective patient management.