Nickel-Catalyzed Reductive Coupling for Transforming Unactivated Aryl Electrophiles into β-Fluoroethylarenes
Yi Yang1, Gen Luo1, Youlin Li1
1College of Chemistry and Environmental Engineering, Sichuan University of Science&Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
Abstract:
We report herein a facile synthetic method for converting unactivated (hetero)aryl electrophiles into β-fluoroethylated (hetero)arenes via nickel-catalyzed reductive cross-couplings. This coupling reaction features the involvement of FCH2 CH2 radical intermediate rather than β-fluoroethyl manganese species which provides effective solutions to the problematic β-fluoride side eliminations. The practical value of this protocol is further demonstrated by the late-stage modification of several complex ArCl or ArOH-derived bioactive molecules.
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