Cerium catalyst promoted C-S cross-coupling: synthesis of thioethers, dapsone and RN-18 precursors
José M da C Tavares Junior1, Caren D G da Silva, Beatriz F Dos Santos
1Organic Catalysis and Biocatalysis Laboratory - LACOB, Federal University of Grande Dourados - UFGD, Dourados, MS, Brazil. nelsondomingues@ufgd.edu.br.
Abstract:
In this work, we present a novel, efficient and green methodology for the synthesis of thioethers by the C-S cross-coupling reaction with the assistance of [Ce(l-Pro)2]2Ox as a heterogeneous catalyst in good to excellent yields. A scale-up of the protocol was explored using an unpublished methodology for the synthesis of a dapsone-precursor, which proved to be very effective over a short time. The catalyst [Ce(l-Pro)2]2Ox was recovered and it was shown to be effective for five more reaction cycles.
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