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Disulfide-Based Self-Immolative Linkers and Functional Bioconjugates for Biological Applications

Zhengyu Deng1, Jinming Hu1, Shiyong Liu1

  • 1CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, China.

Macromolecular Rapid Communications
|November 23, 2019
PubMed
Summary

Disulfide self-immolative linkers (DSILs) offer a versatile method to mask and activate bioactive agents. DSILs overcome limitations of direct disulfide conjugation for improved therapeutic and diagnostic applications.

Keywords:
disulfidesimagingprodrugsresponsive polymersself-immolative linkers

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