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The Blood-brain Barrier00:49

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Blood brain barrier: A tissue engineered microfluidic chip.

Sikkandhar Musafargani1, Sachin Mishra1, Miklós Gulyás2

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, 636921, Singapore.

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Developing advanced blood-brain barrier (BBB) models using microfluidics and stem cells is crucial for effective neurotherapeutics. These innovative

Keywords:
BBB-on-a-ChipBlood-brain barrierMicrofluidicsPermeabilityShear stress

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Drug Delivery

Background:

  • Neurological diseases like Alzheimer's disease necessitate improved therapeutic strategies.
  • The blood-brain barrier (BBB) presents a significant obstacle for drug delivery to the brain.
  • Existing in vitro models lack the physiological relevance of the in vivo environment.

Purpose of the Study:

  • To review current microfluidic approaches for modeling the blood-brain barrier (BBB).
  • To highlight the potential of BBB-on-a-Chip systems for neurotherapeutics and drug development.
  • To discuss limitations of existing BBB models and future directions.

Main Methods:

  • Utilizing microfluidic systems to create a 'laboratory-on-a-chip' environment.
  • Employing human-derived stem cells to engineer a high-fidelity BBB model.
  • Integrating 3D printing technology for robust and reproducible model fabrication.

Main Results:

  • Microfluidic BBB-on-a-Chip models offer a controlled microenvironment for studying barrier properties.
  • These models enable real-time monitoring and possess advantages in fluid delivery and fabrication.
  • Stem cell versatility and 3D printing enhance the development of reliable BBB models.

Conclusions:

  • Microfluidic BBB models represent a significant advancement over traditional in vitro methods.
  • These models hold promise for accelerating neurotherapeutic development and drug discovery.
  • Further interdisciplinary engineering efforts are needed to overcome current technological limitations.