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Etidronate halts systemic arterial calcification in pseudoxanthoma elasticum
Jonas W Bartstra1, Pim A de Jong1, Guido Kranenburg2
1Department of Radiology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Atherosclerosis
|November 23, 2019
Summary
Etidronate treatment effectively halts arterial calcification in pseudoxanthoma elasticum (PXE) patients across most vascular beds. This study confirms etidronate
Area of Science:
- Vascular Biology and Medicine
- Pharmacology and Therapeutics
- Medical Imaging and Diagnostics
Background:
- Pseudoxanthoma elasticum (PXE) is characterized by low inorganic pyrophosphate levels, leading to extensive arterial calcification.
- Previous research indicated etidronate halts femoral artery calcification in PXE patients.
- This study investigates etidronate's efficacy across diverse vascular regions.
Purpose of the Study:
- To evaluate the effectiveness of etidronate in preventing or reducing arterial calcification in various vascular beds in PXE patients.
- To analyze the impact of etidronate on total arterial calcification burden.
Main Methods:
- A post-hoc analysis of the Treatment of Ectopic Mineralization in PXE (TEMP) trial was conducted.
- Computed tomography (CT) was used to quantify arterial calcification mass in multiple vascular segments at baseline and after one year.
- Calcification progression was compared between patients receiving etidronate and those receiving a placebo.
Main Results:
- Etidronate significantly halted calcification progression in all evaluated vascular beds except the coronary arteries.
- The total arterial calcification score showed a significant reduction in the etidronate group compared to the placebo group.
- Median absolute increase in mass score was -63.6 for etidronate vs. 113.7 for placebo (p < 0.01).
Conclusions:
- Etidronate treatment demonstrates a systemic effect in halting arterial calcification in PXE.
- Further investigation is warranted to assess the long-term safety and clinical impact of etidronate in PXE patients.
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