Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.2K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.2K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

893
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
893
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

15.9K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
15.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contemporary Validation of the Renal Cell Carcinoma Inflammatory Score (RISK) for Preoperative Prognostication in Non-Metastatic Renal Cell Carcinoma.

Urology practice·2026
Same author

Evaluating the Diagnostic Performance of Clear Cell Likelihood Score in Predicting Clear Cell Renal Cell Carcinoma Among Patients Younger Than 50 Years.

JCO oncology practice·2026
Same author

Blue versus white light for transurethral resection of non-muscle invasive bladder cancer.

The Cochrane database of systematic reviews·2026
Same author

Combining Serum Prostate Health Index With Urinary PCA3 and TMPRSS2:ERG RNA Testing Improves Detection of Clinically Significant Prostate Cancer.

JU open plus·2026
Same author

Case Report: Looks can deceive: acute postoperative progressive renal dysfunction and hyperkalemia without significant hydronephrosis.

Frontiers in oncology·2026
Same author

Combination Treatment with Intravesical Interferon-Alpha Gene Therapy and Oral Pan-ErbB Receptor Family Blocker Improves Survival in Mice with Bladder Cancer.

bioRxiv : the preprint server for biology·2026
Same journal

An Unprecedented Era of Innovation in Non-Muscle-Invasive Bladder Cancer.

The Urologic clinics of North America·2026
Same journal

Hubert Humphrey's Bladder Cancer: If He Could Have Time Traveled, Would that Have Changed the Outcome?

The Urologic clinics of North America·2026
Same journal

Key Clinical Trials Shaping the Future of Superficial High-Risk Bladder Cancer Management.

The Urologic clinics of North America·2026
Same journal

Future Directions: Artificial Intelligence and Digital Tools in Bladder Cancer Care.

The Urologic clinics of North America·2026
Same journal

Economic Considerations in the Management of Superficial Bladder Cancer.

The Urologic clinics of North America·2026
Same journal

Patient-Centered Approaches to Non-Muscle-Invasive Bladder Cancer Care.

The Urologic clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jan 3, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

13.0K

Intravesical Gene Therapy.

Vikram M Narayan1, Colin P N Dinney2

  • 1University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1373, Houston, TX 77030, USA. Electronic address: https://twitter.com/VikramNarayan.

The Urologic Clinics of North America
|November 24, 2019
PubMed
Summary
This summary is machine-generated.

Non-muscle-invasive bladder cancer (NMIBC) unresponsive to bacillus Calmette-Guerin (BCG) treatment presents challenges. Intravesical gene therapy offers a promising alternative for patients unable or unwilling to undergo radical cystectomy.

Keywords:
BCG-unresponsiveBladder cancerImmunogene therapyInterferon-alphaIntravesical gene therapy

More Related Videos

Lumbar Intrathecal Injection of Gene Therapy Vectors for Central Nervous System Targeting in Mice and Rats
05:09

Lumbar Intrathecal Injection of Gene Therapy Vectors for Central Nervous System Targeting in Mice and Rats

Published on: May 16, 2025

2.7K
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
12:30

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

10.1K

Related Experiment Videos

Last Updated: Jan 3, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

13.0K
Lumbar Intrathecal Injection of Gene Therapy Vectors for Central Nervous System Targeting in Mice and Rats
05:09

Lumbar Intrathecal Injection of Gene Therapy Vectors for Central Nervous System Targeting in Mice and Rats

Published on: May 16, 2025

2.7K
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
12:30

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

10.1K

Area of Science:

  • Oncology
  • Urology
  • Gene Therapy

Background:

  • Non-muscle-invasive bladder cancer (NMIBC) is difficult to treat, especially when unresponsive to bacillus Calmette-Guerin (BCG) therapy.
  • Radical cystectomy with pelvic lymphadenectomy is the standard treatment for BCG-unresponsive NMIBC.
  • There is a significant need for alternative treatments for patients who cannot or will not undergo surgery.

Purpose of the Study:

  • To explore intravesical gene therapy as a potential treatment for BCG-unresponsive NMIBC.
  • To highlight the unmet need for salvage options in NMIBC management.
  • To discuss the emerging role of gene therapy in bladder cancer treatment.

Main Methods:

  • Review of current treatment landscape for NMIBC.
  • Exploration of intravesical gene therapy as a novel therapeutic approach.
  • Discussion of early data and ongoing research in gene therapy for bladder cancer.

Main Results:

  • Intravesical gene therapy shows promise as an alternative to radical cystectomy.
  • Early data suggests potential efficacy in treating BCG-unresponsive NMIBC.
  • Further research is needed to optimize gene therapy mechanisms and outcomes.

Conclusions:

  • Intravesical gene therapy represents a potential breakthrough for managing challenging NMIBC cases.
  • This approach addresses the limitations of current salvage options.
  • Understanding the mechanisms of action is crucial for advancing gene therapy in bladder cancer treatment.