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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors

Hua Zhou1, Meredeth A McGowan1, Kathryn Lipford1

  • 1Department of Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.

Bioorganic & Medicinal Chemistry Letters
|November 24, 2019
PubMed

Keywords:
PI3Kδ inhibitorParallel medicinal chemistryPhosphoinositide 3-kinase δPhysicochemical propertiesStructure-activity relationship

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