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Updated: Sep 18, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
Published on: October 31, 2013
Charge-modulated forward-backward current blockade asymmetry in conical nanopores
Dapeng Chen1,2, Fei Zheng3, Quan Han4
1Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, School of Mechanical Engineering, Southeast University, Nanjing 211100, China. major212@seu.edu.cn.
Abstract:
Conical nanopores reveal charge-dependent current blockade asymmetry during biomolecule translocation. DNA produced larger forward than backward blockades, whereas IgG and BSA showed nearly symmetric responses. Finite-element simulations attribute this behavior to charge-modulated coupling between concentration polarization and ion exclusion, providing charge-sensitive information about biomolecular translocation.
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