Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

15.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.8K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

15.7K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
15.7K
Inflammation01:38

Inflammation

61.3K
Overview
61.3K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.5K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.5K
T Cell Types and Functions01:24

T Cell Types and Functions

2.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.2K
Overview
83.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2.

Vaccines·2025
Same author

To be remembered: B cell memory response against SARS-CoV-2 and its variants in vaccinated and unvaccinated individuals.

Scandinavian journal of immunology·2024
Same author

Severe disease during both primary and secondary dengue virus infections in pediatric populations.

Nature medicine·2024
Same author

Phytochemical Screening of Nyctanthes arbor-tristis Plant Extracts and Their Antioxidant and Antibacterial Activity Analysis.

Applied biochemistry and biotechnology·2023
Same author

NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat liver: Effect of resveratrol and metformin.

Life sciences·2020
Same author

Antibody response patterns in chikungunya febrile phase predict protection versus progression to chronic arthritis.

JCI insight·2020

Related Experiment Video

Updated: Jan 3, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

12.0K

Host inflammatory responses to intracellular invaders: Review study.

Ramesh Chandra Rai1

  • 1International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India.

Life Sciences
|November 24, 2019
PubMed
Summary

Host immune systems use inflammasomes to detect pathogens and trigger inflammation. Activated inflammasomes lead to pyroptosis, a cell death mechanism that eliminates infected cells and controls pathogen spread.

Keywords:
InfectionInflammasomeInflammationPathogenPattern recognition receptors

More Related Videos

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.7K
Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

10.8K

Related Experiment Videos

Last Updated: Jan 3, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

12.0K
Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.7K
Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

10.8K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Host immune responses are crucial for pathogen clearance.
  • Pattern recognition receptors (PRRs) detect pathogen-associated molecular patterns (PAMPs).
  • Inflammatory responses are early host defense strategies regulated by molecular pathways.

Purpose of the Study:

  • To explain the role of inflammasomes in host defense against pathogens.
  • To elucidate the mechanism of inflammasome activation and its downstream effects.

Main Methods:

  • The study focuses on the molecular components and activation pathways of inflammasomes.
  • It describes the cleavage of pro-caspase-1 and Gasdermin D by activated caspase-1.

Main Results:

  • Inflammasomes, comprising NLRP3, ASC, and caspase, assemble upon infection or injury.
  • Activated caspase-1 processes pro-inflammatory cytokines (IL-1β, IL-18) and cleaves Gasdermin D.
  • Cleaved Gasdermin D forms pores, inducing pyroptosis and controlling pathogen establishment.

Conclusions:

  • Inflammasomes are key drivers of inflammation and pyroptosis during infection.
  • These processes are essential for host defense and pathogen containment.