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Origin and development of classical dendritic cells

Pierre Guermonprez1, Yohan Gerber-Ferder2, Kristine Vaivode3

  • 1King's College London, Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immmunobiology, London, United Kingdom; Université de Paris, CNRS ERL8252, INSERM1149, Centre for Inflammation Research, Paris, France.

International Review of Cell and Molecular Biology
|November 25, 2019
PubMed

Insights

Classical dendritic cells (cDCs) are key immune cells. This study explores their development from hematopoietic stem cells, focusing on the pathways that specify distinct cDC subsets.

Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • Classical dendritic cells (cDCs) are crucial for adaptive immunity, but distinguishing them from other phagocytes is challenging.
  • Current definitions incorporate ontogenetic features, including dependence on specific growth factors and transcription factors like ZBTB46.
  • cDCs comprise heterogeneous subsets (type 1 and type 2) with distinct developmental origins.

Purpose of the Study:

  • To review recent findings on the cellular and molecular mechanisms controlling cDC subset specification.
  • To elucidate the ontogenetic pathways of cDC subsets from hematopoietic stem cells in mice and humans.

Main Methods:

  • Review of recent scientific literature on dendritic cell development.
  • Analysis of cellular and molecular pathways involved in cDC subset specification.
  • Comparative study of murine and human hematopoietic stem cell differentiation.

Main Results:

  • cDC definition increasingly relies on ontogenetic features beyond surface markers.
  • Two main cDC subsets, type 1 and type 2, arise from divergent developmental routes.
  • Understanding these pathways is key to distinguishing cDC subsets.

Conclusions:

  • Classical dendritic cells (cDCs) are defined by a combination of ontogenetic and functional criteria.
  • Recent advances highlight the divergent pathways governing type 1 and type 2 cDC subset development.
  • Further research into these pathways offers insights into immune regulation.

Keywords:
Dendritic cellsHematopoiesisOntogeny

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