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Neuroimaging of Deep Brain Stimulation.
Lorand Eross1, Jonathan Riley2, Elad I Levy3
1Department of Functional Neurosurgery, Center of Neuromodulation, National Institute of Clinical Neurosciences, Amerikai út 57, Budapest 1145, Hungary.
Neurologic Clinics
|November 26, 2019
Summary
Deep brain stimulation (DBS) is a key neuromodulation therapy. Imaging, like diffusion tensor imaging, enhances DBS surgical precision and outcomes for movement disorders and epilepsy, advancing neuroscience.
Area of Science:
- Neurosurgery and Neuroscience
Background:
- Deep brain stimulation (DBS) is a leading neuromodulation therapy for Parkinson disease, essential tremor, and generalized dystonia.
- Advancements in imaging techniques are crucial for refining surgical procedures and improving patient outcomes.
Purpose of the Study:
- To explore how imaging technologies enhance surgical techniques and outcomes in neuromodulation therapies.
- To discuss the role of imaging in advancing translational neuroscience for movement disorders and epilepsy.
Main Methods:
- Utilizing diffusion tensor imaging (DTI) for precise anatomical segmentation of cortical areas and deep brain targets.
- Employing visualization of white matter tracts to improve surgical navigation and safety.
Main Results:
- DTI enables detailed understanding of functional subregions within deep brain targets, aiding in the analysis of stimulation side effects and therapeutic mechanisms.
- White matter tract visualization significantly enhances the safety of neurosurgical techniques in functional neurosurgery and neuro-oncology.
Conclusions:
- Imaging, particularly DTI, is pivotal in optimizing deep brain stimulation surgery for movement disorders and epilepsy.
- Enhanced visualization through imaging improves surgical precision, safety, and contributes to a deeper understanding of neuromodulation mechanisms.
