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Updated: Jan 3, 2026

Sulfate Separation by Selective Crystallization with a Bis-iminoguanidinium Ligand
Published on: September 8, 2016
One-Pot Absolute Stereochemical Identification of Alcohols via Guanidinium Sulfate Crystallization
Beau R Brummel1, Kinsey G Lee1, Colin D McMillen1
1Department of Chemistry , Clemson University , Clemson , South Carolina 29634 , United States.
Abstract:
A novel technique for the absolute stereochemical determination of alcohols has been developed that uses crystallization of guanidinium salts of organosulfates. The simple one-pot, two-step process leverages facile formation of guandinium organosulfate single crystals for the straightforward determination of the absolute stereochemistry of enantiopure alcohols by means of X-ray crystallography. The strong hydrogen bonding network drives the stability of the crystal lattice and allows for a diverse range of organic alcohol substrates to be analyzed.
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