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Gender and Hemispheric Differences in Epilepsy Diagnosed by Voxel-based Morphometry (VBM) Method: a Pilot Cortical
Shahid Bashir1, Raidah Baradi1, Fouad Al-Ghamdi1
1Neuroscience Center, King Fahd Specialist Hospital Dammam, Dammam, Saudi Arabia.
Summary
Epilepsy patients show widespread brain abnormalities, particularly on the left side. Gender influences the location of these changes, with females exhibiting temporal lobe differences and males showing frontal lobe alterations.
Area of Science:
- Neuroimaging
- Neuroanatomy
- Epilepsy Research
Background:
- Voxel-based morphometry (VBM) enables detailed analysis of brain anatomy.
- Gender significantly impacts brain structure and function.
- Epilepsy is associated with various neurological alterations.
Purpose of the Study:
- To investigate gender-specific anatomical differences in epilepsy patients using VBM.
- To identify hemispheric variations in brain structure among individuals with epilepsy.
- To correlate brain abnormalities with gender and laterality in epilepsy.
Main Methods:
- Whole-brain cortical thickness analysis was conducted.
- Voxel-based morphometry (VBM) was employed for statistical analysis.
- Comparison between 28 epilepsy patients and 30 healthy controls.
Main Results:
- Epilepsy patients exhibited more widespread cortical thickness abnormalities on the left side of the brain.
- Females with epilepsy showed changes predominantly in temporal regions.
- Males with epilepsy had more affected frontal regions.
Conclusions:
- Gender and brain laterality are critical factors in understanding brain damage patterns in epilepsy.
- VBM effectively highlights gender-based anatomical differences in epilepsy.
- Findings contribute to the understanding of sex-specific neurobiological underpinnings of epilepsy.
