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Does Salivary Function Decrease in Proportion to Radioiodine Dose?
Ji Won Kim1, Jeong Mi Kim1, Mi Eun Choi1
1Department of Otolaryngology, Inha University, School of Medicine, Incheon.
The Laryngoscope
|November 26, 2019
Summary
Radioiodine negatively impacts salivary glands in a dose-dependent manner, causing long-term damage and impaired function. These findings are crucial for managing radioiodine therapy doses.
Area of Science:
- Nuclear Medicine
- Toxicology
- Histopathology
Background:
- Radioiodine is widely used in treating thyroid conditions.
- Salivary gland toxicity is a known side effect of radioiodine therapy.
- Understanding the dose-response relationship is critical for patient safety.
Purpose of the Study:
- To investigate the dose-response characteristics of radioiodine on salivary glands.
- To elucidate the mechanisms underlying radioiodine-induced salivary gland toxicity.
Main Methods:
- Mice were administered varying oral doses of radioiodine.
- Evaluated outcomes included mortality, body and gland weights, salivary function tests, and histopathological changes.
- Assessed 99mTc pertechnetate uptake/excretion, cell populations, oxidative stress, and apoptosis.
Main Results:
- Increased radioiodine doses led to decreased survival, body weight, gland weight, and salivary flow rate, with increased lag times.
- Histopathology revealed acinar atrophy, ductal dilation, lymphocytic infiltration, and epithelial damage.
- Radioiodine impaired 99mTc pertechnetate uptake/excretion, altered cell populations, increased oxidative stress, and induced apoptosis.
Conclusions:
- Radioiodine causes dose-related, long-term adverse effects on salivary glands.
- These findings necessitate careful consideration of radioiodine dosage in clinical practice.
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