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Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
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Reprogramming of cellular metabolic pathways by human oncogenic viruses
John G Purdy1, Micah A Luftig2
1Department of Immunobiology, BIO5 Institute, University of Arizona, 1657 East Helen St, Keating Bldg Rm424, Tucson, AZ 85719, United States.
Current Opinion in Virology
|November 26, 2019
Summary
Oncogenic viruses reprogram host metabolism for replication, similar to how cancer cells alter metabolism for growth. This review explores these shared metabolic reprogramming strategies.
Area of Science:
- Virology
- Cancer Biology
- Metabolic Research
Background:
- Viruses require host cell metabolism for replication.
- Oncogenic viruses and cancer share metabolic reprogramming similarities.
- Viral oncogenes can independently alter host metabolism.
Purpose of the Study:
- To review the parallels in metabolic reprogramming between oncogenic viruses and cancer.
- To highlight shared metabolic demands for biomass production in viral infection and cancer development.
Main Methods:
- Literature review of studies on viral oncogenes and host metabolism.
- Comparative analysis of metabolic pathways in viral infections and oncogenesis.
- Discussion of metabolic reprogramming strategies in DNA tumor viruses and retroviruses.
Main Results:
- Both viral infection and cancer necessitate increased metabolic activity.
- Oncogenic viruses reprogram host metabolism to support virion production.
- Shared metabolic pathways are exploited by viruses and cancer cells for proliferation.
Conclusions:
- Metabolic reprogramming is a critical commonality between oncogenic viruses and cancer.
- Understanding these shared metabolic alterations may reveal new therapeutic targets.
- Further research into virus-host metabolic interactions is warranted.
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