A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution
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Updated: Jan 3, 2026

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
Published on: December 30, 2015
Jonas Handwerker1,2, Marlon Pérez-Rodas3,4, Michael Beyerlein5
1Institute of Smart Sensors, University of Stuttgart, Stuttgart, Germany. jonas.handwerker@iis.uni-stuttgart.de.
Abstract:
Magnetic resonance imaging and spectroscopy are versatile methods for probing brain physiology, but their intrinsically low sensitivity limits the achievable spatial and temporal resolution. Here, we introduce a monolithically integrated NMR-on-a-chip needle that combines an ultra-sensitive 300 µm NMR coil with a complete NMR transceiver, enabling in vivo measurements of blood oxygenation and flow in nanoliter volumes at a sampling rate of 200 Hz.

