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Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart

Shohei Ikeda1,2, Risa Mukai1, Wataru Mizushima1

  • 1Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey.

JACC. Basic to Translational Science
|November 27, 2019
PubMed

Keywords:
HF, heart failureHFD, high-fat dietHippo pathwayLV, left ventricularLats2, large tumor suppressor kinase 2Mst1, mammalian sterile 20-like 1ND, normal dietOSM, oncostatin MPO, pressure overloadRunx1, runt-related transcription factor 1TAC, transverse aortic constrictionTAZ, transcriptional coactivator with PDZ-binding motifTEAD, transcriptional enhancer factorYAP, Yes-associated proteindiabetesdiabetic cardiomyopathypressure overload

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